Sulfuric Acid → HCID 45085627, compound

Participants

Reaction Steps

In a similar manner to that of Example 37, (3R,4R)-3-ethyl-4-trimethylsilylethynyl-2-azetidinone (0.18 g) is reacted with mercuric sulfate (0.05 g) and concentrated sulfuric acid (trace). To the reaction mixture is added sodium bicarbonate (0.1 g) and then evaporated under reduced pressure. The residue is extracted with a mixture of ethyl acetate (30 ml) and THF (30 ml), and then evaporated under reduced pressure. The residue is subjected to a column chromatography on silica gel (eluent: 50% ethyl acetate in hexane) to give (3R,4R)-4-acetyl-3-ethyl-2-azetidinone (0.08 g).

Provenance & Evidence