Methanol → 4-(4-(aminomethyl)-4-fluoropiperidin-1-yl)-N-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-6-yl)furo[3,2-d]pyrimidin-2-amine

HRID 2312435Notes

Reaction equation

HRID 2312435 reaction equation
[CH3:70][Si:71]([CH3:72])([CH3:73])[CH2:74][CH2:75][O:76][CH2:77][n:78]1[c:79]2[c:80]([cH:81][cH:82][c:83]([NH2:84])[cH:85]2)[cH:86][n:87]1.[CH3:91][OH:92].[Cl:59][c:60]1[n:61][c:62]([Cl:63])[c:64]2[o:65][cH:66][cH:67][c:68]2[n:69]1.[F:1][C:2]1([CH2:35][N:36]2[C:37](=[O:38])[c:39]3[c:40]([cH:41][cH:42][cH:43][cH:44]3)[C:45]2=[O:46])[CH2:3][CH2:4][N:5]([c:8]2[c:9]3[c:10]([n:11][c:12]([NH:14][c:15]4[cH:16][cH:17][c:18]5[cH:19][n:20][n:21]([CH2:24][O:25][CH2:26][CH2:27][Si:28]([CH3:29])([CH3:30])[CH3:31])[c:22]5[cH:23]4)[n:13]2)[cH:32][cH:33][o:34]3)[CH2:6][CH2:7]1.[NH2:47][C:48]([c:49]1[c:50]([C:51](=[O:52])[NH2:53])[cH:54][cH:55][cH:56][cH:57]1)=[O:58].[NH2:89][NH2:90].[OH2:88]>>[F:1][C:2]1([CH2:35][NH2:36])[CH2:3][CH2:4][N:5]([c:8]2[c:9]3[c:10]([n:11][c:12]([NH:14][c:15]4[cH:16][cH:17][c:18]5[cH:19][n:20][n:21]([CH2:24][O:25][CH2:26][CH2:27][Si:28]([CH3:29])([CH3:30])[CH3:31])[c:22]5[cH:23]4)[n:13]2)[cH:32][cH:33][o:34]3)[CH2:6][CH2:7]1

Participants

8

Reactant 7

HCID 887MethanolHCID 962WaterHCID 6956PhthalamideHCID 9321HydrazineHCID 457899682,4-Dichlorofuro[3,2-D]pyrimidineHCID 67293196HCID 67293196, compoundHCID 687527592-((4-fluoro-1-(2-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-6-ylamino)furo[3,2-d]pyrimidin-4-yl)piperidin-4-yl)methyl)isoindoline-1,3-dione

Product 1

HCID 687487904-(4-(aminomethyl)-4-fluoropiperidin-1-yl)-N-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-6-yl)furo[3,2-d]pyrimidin-2-amine

Sources & evidence

ORD record
ord-683a9fd9a14147629413e55e312dd380
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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