反应详情

2-Amino-5-tert-butyl-1,3,4-thiadiazole (1.57 g) and 2,3-dimethylmaleic anhydride (1.51 g) were refluxed for 5 hours in glacial acetic acid (30 ml). After the reaction, acetic acid and the excess of the 2,3-dimethylmaleic anhydride were evaporated. The residue was dissolved in dichloromethane (50 ml), and the solution was washed with a 10% aqueous solution of potassium carbonate (20 ml), and dried over anhydrous magnesium sulfate. The solvent was evaporated to give the desired N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)-2,3-dimethylmaleinimide (2.41 g), mp. 87°-91° C.

1. customthe excess of the 2,3-dimethylmaleic anhydride were evaporated
2. dissolutionThe residue was dissolved in dichloromethane (50 ml)
3. washthe solution was washed with a 10% aqueous solution of potassium carbonate (20 ml)
4. dry with materialdried over anhydrous magnesium sulfate
5. customThe solvent was evaporated