Triethylamine → HCID 20034824, compound

Participants

Reaction Steps

In 50 ml of dichloromethane is dissolved 2.5 g of 4-[(3-octadecyloxy-2-methoxypropyl)sulfonyl]butanol, to which 0.78 g of methanesulfonyl chloride and 0.95 ml of triethylamine are added dropwise with stirring under ice cooling. After being stirred at room temperature for 40 minutes, the mixture is washed with water, an aqueous sodium bicarbonate solution and water, and dried. The solvent is distilled off under reduced pressure to leave 2.76 g of 4-mesyloxybutyl 3-octadecyloxy-2-methoxypropyl sulfone. This is dissolved in 40 ml of toluene containing 8 g of trimethylamine, and the solution is stirred at room temperature for 40 hours. The reaction mixture is concentrated and reprecipitated from chloroform-acetone to give 2.1 g of the captioned compound.

Provenance & Evidence