3-Mercaptopropanol → HCID 53807292, compound

Participants

Reaction Steps

To 30 ml of teterahydrofuran are added 11.8 ml of a methanol solution of sodium methoxide (28% solution), 0.57 g of sodium borohydride and 4.14 g of 3-mercaptopropanol, to which is added dropwise a solution of 6.97 g of 2-methoxy-3(3,7,11,15-tetramethylhexadecyloxy)propyl methanesulfonate in 50 ml of tetrahydrofuran at room temperature with stirring under nitrogen streams. Thereafter, the reaction mixture is stirred at room temperature for 16 hours. The solvent is distilled off under reduced pressure and the residue is extracted with hexane. The extract layer is washed successively with water, dilute hydrochloric acid, water, an aqueous sodium bicarbonate solution and then with water. After drying, the solvent is distilled off under reduced pressure to leave 6.67 g of the captioned compound as an oily substance.

Provenance & Evidence