6-((3-((2-(4-(2-Aminoethyl)phenoxy)ethyl)(methyl)carbamoyl)phenyl)sulfonyl)-4-((3-methoxyphenyl)amino)-8-methylquinoline-3-carboxamide → 6-[3-[2-[4-[2-[[2-[tert-butyl(dimethyl)silyl]oxy-2-(2-oxo-8-phenylmethoxy-1H-quinolin-5-yl)ethyl]amino]ethyl]phenoxy]ethyl-methylcarbamoyl]phenyl]sulfonyl-4-(3-methoxyanilino)-8-methylquinoline-3-carboxamide

HRID 2313337Notes

Reaction equation

[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][cH:11][c:12]([CH:20]([CH2:21][NH:22][CH2:23][CH2:24][c:25]2[cH:26][cH:27][c:28]([NH:29][C:30]([c:31]3[cH:32][c:33]([S:34]([c:35]4[cH:36][c:37]5[c:38]([c:39]([CH3:40])[cH:41]4)[n:42][cH:43][c:44]([C:45]([NH2:46])=[O:47])[c:48]5[NH:49][c:50]4[cH:51][cH:52][cH:53][c:54]([O:55][CH3:56])[cH:57]4)(=[O:58])=[O:59])[cH:60][cH:61][cH:62]3)=[O:63])[cH:64][cH:65]2)[O:66][Si:67]([CH3:68])([CH3:69])[C:70]([CH3:71])([CH3:72])[CH3:73])[c:13]2[cH:14][cH:15][c:16](=[O:19])[nH:17][c:18]12.[NH2:74][CH2:75][CH2:76][c:77]1[cH:78][cH:79][c:80]([O:81][CH2:82][CH2:83][N:84]([C:85](=[O:86])[c:87]2[cH:88][c:89]([S:93](=[O:94])(=[O:95])[c:96]3[cH:97][c:98]4[c:99]([NH:110][c:111]5[cH:112][c:113]([O:117][CH3:118])[cH:114][cH:115][cH:116]5)[c:100]([C:107](=[O:108])[NH2:109])[cH:101][n:102][c:103]4[c:104]([CH3:106])[cH:105]3)[cH:90][cH:91][cH:92]2)[CH3:119])[cH:120][cH:121]1>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][cH:11][c:12]([CH:20]([CH2:21][NH:74][CH2:75][CH2:76][c:77]2[cH:78][cH:79][c:80]([O:81][CH2:82][CH2:83][N:84]([C:85](=[O:86])[c:87]3[cH:88][c:89]([S:93](=[O:94])(=[O:95])[c:96]4[cH:97][c:98]5[c:99]([NH:110][c:111]6[cH:112][c:113]([O:117][CH3:118])[cH:114][cH:115][cH:116]6)[c:100]([C:107](=[O:108])[NH2:109])[cH:101][n:102][c:103]5[c:104]([CH3:106])[cH:105]4)[cH:90][cH:91][cH:92]3)[CH3:119])[cH:120][cH:121]2)[O:66][Si:67]([CH3:68])([CH3:69])[C:70]([CH3:71])([CH3:72])[CH3:73])[c:13]2[cH:14][cH:15][c:16](=[O:19])[nH:17][c:18]12

Participants

Reactant 2

HCID 669883066-((3-((2-(4-(2-Aminoethyl)phenoxy)ethyl)(methyl)carbamoyl)phenyl)sulfonyl)-4-((3-methoxyphenyl)amino)-8-methylquinoline-3-carboxamide

HCID 872263886-[3-[[4-[2-[[2-[tert-butyl(dimethyl)silyl]oxy-2-(2-oxo-8-phenylmethoxy-1H-quinolin-5-yl)ethyl]amino]ethyl]phenyl]carbamoyl]phenyl]sulfonyl-4-(3-methoxyanilino)-8-methylquinoline-3-carboxamide

Product 1

HCID 893500446-[3-[2-[4-[2-[[2-[tert-butyl(dimethyl)silyl]oxy-2-(2-oxo-8-phenylmethoxy-1H-quinolin-5-yl)ethyl]amino]ethyl]phenoxy]ethyl-methylcarbamoyl]phenyl]sulfonyl-4-(3-methoxyanilino)-8-methylquinoline-3-carboxamide

Sources & evidence

ORD record: ord-ac55f4cdd41248b6968d8732bb71091d
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (10/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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