Chlorotrimethylsilane → HCID 54480533, compound

Participants

Reaction Steps

In 15 ml of acetonitrile was dissolved 795 mg of methyl 2-methoxyimino-3-oxobutyrate, followed by addition of 2.1 ml of triethylamine. Then, 1.9 ml of chlorotrimethylsilane was added dropwise with ice-cooling and the mixture was stirred at 20°-25° C. for 1 hour for silylation. The reaction mixture was concentrated under reduced pressure and the residue was suspended in 10 ml of carbon tetrachloride and the suspension was filtered in a nitrogen gas stream to remove insolubles. The filtrate was concentrated under reduced pressure to give 1.00 g of methyl 2-methoxyimino-3-trimethylsilyloxy-3-butenoate as oil. Yield 86.5%.

Provenance & Evidence