6-[2-(5-Chloro-2,4-dimethoxy-phenyl)ethyl]-6-cyclopentyl-tetrahydropyran-2,4-dione → 6-[2-(5-Chloro-2,4-dimethoxy-phenyl)-ethyl]-6-cyclopentyl-4-hydroxy-3-(2-methyl-1H-imidazol-4-ylmethyl)-5,6-dihydro-pyran-2-one

HRID 2313411Notes

Reaction equation

HRID 2313411 reaction equation
[CH3:53][c:54]1[nH:55][cH:56][c:57]([CH:59]=[O:60])[n:58]1.[CH3:61][c:62]1[cH:63][c:64]([CH3:65])[n:66]2[n:67][c:68]([CH:69]=[O:70])[n:71][c:72]2[n:73]1.[Cl:1][c:2]1[c:3]([O:25][CH3:26])[cH:4][c:5]([O:23][CH3:24])[c:6]([CH2:8][CH2:9][C:10]2([CH:18]3[CH2:19][CH2:20][CH2:21][CH2:22]3)[CH2:11][C:12](=[O:17])[CH2:13][C:14](=[O:16])[O:15]2)[cH:7]1.[Cl:27][c:28]1[cH:29][c:30]([CH2:31][CH2:32][C:33]2([CH:34]3[CH2:35][CH2:36][CH2:37][CH2:38]3)[O:39][C:40](=[O:41])[CH2:42][C:43](=[O:44])[CH2:45]2)[cH:46][cH:47][c:48]1[O:49][CH:50]([CH3:51])[CH3:52]>>[Cl:1][c:2]1[c:3]([O:25][CH3:26])[cH:4][c:5]([O:23][CH3:24])[c:6]([CH2:8][CH2:9][C:10]2([CH:18]3[CH2:19][CH2:20][CH2:21][CH2:22]3)[CH2:11][C:12]([OH:17])=[C:13]([CH2:59][c:57]3[cH:56][nH:55][c:54]([CH3:53])[n:58]3)[C:14](=[O:16])[O:15]2)[cH:7]1

Participants

5

Reactant 4

HCID 167287016-[2-(5-Chloro-2,4-dimethoxy-phenyl)ethyl]-6-cyclopentyl-tetrahydropyran-2,4-dioneHCID 167287396-[2-(3-Chloro-4-isopropoxy-phenyl)ethyl]-6-cyclopentyl-tetrahydropyran-2,4-dioneHCID 236352265,7-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carbaldehydeHCID 178418999HCID 178418999, compound

Product 1

HCID 1784934446-[2-(5-Chloro-2,4-dimethoxy-phenyl)-ethyl]-6-cyclopentyl-4-hydroxy-3-(2-methyl-1H-imidazol-4-ylmethyl)-5,6-dihydro-pyran-2-one

Sources & evidence

ORD record
ord-74139a4ed461437697275f30129a8cf7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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