1-(tert-Butoxycarbonyl)-4-(methanesulfonyloxy)piperidine → Tert-butyl 4-(5-chloro-1-(4-cyano-3-fluorophenyl)-2-oxo-1,2-dihydropyridin-4-yloxy)piperidine-1-carboxylate

HRID 2313644Notes

Reaction equation

HRID 2313644 reaction equation
[CH3:27][S:28]([O:29][CH:32]1[CH2:33][CH2:34][N:35]([C:38](=[O:39])[O:40][C:41]([CH3:42])([CH3:43])[CH3:44])[CH2:36][CH2:37]1)(=[O:30])=[O:31].[CH3:45][S:46]([O:47][CH:48]1[CH2:49][CH2:50][N:51]([c:52]2[n:53][cH:54][c:55]([CH2:56][CH2:57][CH3:58])[cH:59][n:60]2)[CH2:61][CH2:62]1)(=[O:63])=[O:64].[Cl:1][c:2]1[c:3]([OH:18])[cH:4][c:5](=[O:17])[n:6](-[c:8]2[cH:9][c:10]([F:16])[c:11]([C:12]#[N:13])[cH:14][cH:15]2)[cH:7]1.[OH:19][c:20]1[cH:21][cH:22][nH:23][c:24](=[O:25])[cH:26]1>>[Cl:1][c:2]1[c:3]([O:18][CH:32]2[CH2:33][CH2:34][N:35]([C:38](=[O:39])[O:40][C:41]([CH3:42])([CH3:43])[CH3:44])[CH2:36][CH2:37]2)[cH:4][c:5](=[O:17])[n:6](-[c:8]2[cH:9][c:10]([F:16])[c:11]([C:12]#[N:13])[cH:14][cH:15]2)[cH:7]1

Participants

5

Reactant 4

HCID 41848691-(tert-Butoxycarbonyl)-4-(methanesulfonyloxy)piperidineHCID 546960044-Hydroxy-2(1H)-pyridinoneHCID 673665324-(5-chloro-4-hydroxy-2-oxopyridin-1(2H)-yl)-2-fluorobenzonitrileHCID 866262675-Propylpyrimidin-2-ylpiperidin-4-yl methanesulfonate

Product 1

HCID 57468467Tert-butyl 4-(5-chloro-1-(4-cyano-3-fluorophenyl)-2-oxo-1,2-dihydropyridin-4-yloxy)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-cc85d2d4e59142f7a94de245868e2f9e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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