(2-Aminopyrimidin-5-yl)boronic acid → 5-(7-methyl-4-morpholino-6-((4-N-phenylsulfonylpiperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-2-yl)pyrimidin-2-amine

HRID 2313654Notes

Reaction equation

HRID 2313654 reaction equation
[Cl:1][c:2]1[n:3][c:4]([N:28]2[CH2:29][CH2:30][O:31][CH2:32][CH2:33]2)[c:5]2[c:6]([n:7]1)[c:8]([CH3:27])[c:9]([CH2:11][N:12]1[CH2:13][CH2:14][N:15]([S:18](=[O:19])(=[O:20])[c:21]3[cH:22][cH:23][cH:24][cH:25][cH:26]3)[CH2:16][CH2:17]1)[s:10]2.[NH2:34][c:35]1[n:36][cH:37][c:38]([B:41]([OH:42])[OH:43])[cH:39][n:40]1>>[c:2]1(-[c:38]2[cH:37][n:36][c:35]([NH2:34])[n:40][cH:39]2)[n:3][c:4]([N:28]2[CH2:29][CH2:30][O:31][CH2:32][CH2:33]2)[c:5]2[c:6]([n:7]1)[c:8]([CH3:27])[c:9]([CH2:11][N:12]1[CH2:13][CH2:14][N:15]([S:18](=[O:19])(=[O:20])[c:21]3[cH:22][cH:23][cH:24][cH:25][cH:26]3)[CH2:16][CH2:17]1)[s:10]2

Participants

3

Reactant 2

HCID 17750211(2-Aminopyrimidin-5-yl)boronic acidHCID 866235352-Chloro-6-(4-benzenesulfonyl-piperazin-1-ylmethyl)-7-methyl-4-morpholin-4-yl-thieno[3,2-d]pyrimidine

Product 1

HCID 582340505-(7-methyl-4-morpholino-6-((4-N-phenylsulfonylpiperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-2-yl)pyrimidin-2-amine

Sources & evidence

ORD record
ord-1068272b896c456dba4b6c1c1f63933b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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