1-Amino-2-propanol → 4-Chloro-2-(beta-hydroxypropyl)amino-6-(beta-hydroxypropyl)aminonitrobenzene

Participants

Reaction Conditions

Reaction Steps

0.2 mole (45.3 g) of 2,4,6-trichloronitrobenzene is added in small portions to 180 ml of 3-amino-2-propanol heated to 80° C., with stirring. The reaction is exothermic. After heating for 3 hours 30 minutes, the reaction mixture is poured into 180 ml of ice-cold water. The product expected precipitates. It is drained, washed to neutrality with water and then dried under vacuum in the presence of phosphorous pentoxide. After recrystallization from 96° ethanol, it melts at 170° C.

Provenance & Evidence