Thionyl Chloride → HCID 14501734, compound

To a 3-neck 500 ml round-bottom flask equipped with a magnetic stirrer, reflux condenser and addition funnel was added (2,2,2-trifluoroethoxy)acetic acid (30.90 g, 0.196 moles) and 250 ml of chloroform under nitrogen. Thionyl chloride (30.20 g, 0.250 moles) was added dropwise and the solution refluxed for 2 hours. The mixture was then concentrated by distillation of the chloroform and excess thionyl chloride. The remaining yellow oil was distilled in vacuo to give 18.9 g of the product as a colorless oil, bp 40°-48° C./20 mm.

1. customTo a 3-neck 500 ml round-bottom flask equipped with a magnetic stirrer
2. temperaturereflux
3. additioncondenser and addition funnel
4. temperaturethe solution refluxed for 2 hours
5. concentrationThe mixture was then concentrated by distillation of the chloroform and excess thionyl chloride
6. distillationThe remaining yellow oil was distilled in vacuo

ORD record

ord-40681304b10842c7b07f9c5deebeebed

Source dataset

uspto-grants-1989_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04846873