Methanol → 6-(4-Chloro-2-fluoro-3-methoxyphenyl)-4-oxo-1,4,5,6-tetrahydropyridine-2-carboxylic acid methyl ester

HRID 2314050Notes

Reaction equation

HRID 2314050 reaction equation
[CH3:31][O-:32].[CH3:34][OH:35].[Na+:33].[c:1]1([O:2][C:3](=[O:4])[N:10]2[C:11]([C:27](=[O:28])[O:29][CH3:30])=[CH:12][C:13](=[O:26])[CH2:14][CH:15]2[c:16]2[c:17]([F:25])[c:18]([O:23][CH3:24])[c:19]([Cl:22])[cH:20][cH:21]2)[cH:5][cH:6][cH:7][cH:8][cH:9]1>>[NH:10]1[C:11]([C:27](=[O:28])[O:29][CH3:30])=[CH:12][C:13](=[O:26])[CH2:14][CH:15]1[c:16]1[c:17]([F:25])[c:18]([O:23][CH3:24])[c:19]([Cl:22])[cH:20][cH:21]1

Participants

5

Reactant 4

HCID 887MethanolHCID 923Sodium ionHCID 3826051MethoxideHCID 596121126-(4-chloro-2-fluoro-3-methoxyphenyl)-4-oxo-5,6-dihydro-4H-pyridine-1,2-dicarboxylic acid 2-methyl ester 1-phenyl ester

Product 1

HCID 596121066-(4-Chloro-2-fluoro-3-methoxyphenyl)-4-oxo-1,4,5,6-tetrahydropyridine-2-carboxylic acid methyl ester

Sources & evidence

ORD record
ord-491c689ca58249788f947e92b541dc00
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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