反应详情

A mixture of 0.6 g (0.0024 mole) of N-[4-chloro-2-fluoro-5-(1-methoxyethyl)phenyl]acetamide, 0.14 g (0.0025 mole) of potassium hydroxide, 10 ml of water, and 10 ml of methanol was heated at reflux for 24 hours. This mixture was cooled and diluted with 50 ml of water. The resulting mixture was extracted successively with methylene chloride and diethyl ether. The combined extracts were dried, filtered, and the solvent was evaporated under reduced pressure, leaving 0.58 g of 4-chloro-2-fluoro-5-(1-methoxyethyl)aniline as an oil. The nmr spectrum was consistent with the proposed structure.

1. temperaturewas heated
2. temperatureat reflux for 24 hours
3. temperatureThis mixture was cooled
4. extractionThe resulting mixture was extracted successively with methylene chloride and diethyl ether
5. customThe combined extracts were dried
6. filtrationfiltered
7. customthe solvent was evaporated under reduced pressure