Potassium Nitrate → 2-[(2-Chloro-4-fluoro-5-nitrophenyl)methyl]-4,4-dimethyl-3-isoxazolidinone

HRID 231442노트

반응식

HRID 231442 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH2:9][N:10]1[C:14](=[O:15])[C:13]([CH3:17])([CH3:16])[CH2:12][O:11]1.[N+:18]([O-])([O-:20])=[O:19].[K+]>S(=O)(=O)(O)O>[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([N+:18]([O-:20])=[O:19])=[CH:4][C:3]=1[CH2:9][N:10]1[C:14](=[O:15])[C:13]([CH3:17])([CH3:16])[CH2:12][O:11]1

참가 물질

4

반응물 2

HCID 24434Potassium NitrateHCID 131925732-[(2-Chloro-4-fluorophenyl)methyl]-4,4-dimethyl-1,2-oxazolidin-3-one

생성물 1

HCID 200323742-[(2-Chloro-4-fluoro-5-nitrophenyl)methyl]-4,4-dimethyl-3-isoxazolidinone수율 50.8%

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

By the method of Example 3, Step A, 20 g (0.078 mole) of 2-[(2-chloro-4-fluorophenyl)methyl]-4,4-dimethyl-3-isoxazolidinone, 7.8 g (0.78 mole) of potassium nitrate, and 100 ml of concentrated sulfuric acid were reacted, yielding 12 g of 2-[(2-chloro-4-fluoro-5-nitrophenyl)methyl]-4,4-dimethyl-3-isoxazolidinone as a light yellow solid. Passage through a column of silica gel was omitted since the product was crystalline. Purification was accomplished by recrystallization from ethyl acetate/hexane. This reaction was repeated, and the products were combined.

출처 및 근거

ORD 기록
ord-f6ac26398fa44f38b55a50718fbb3436
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04846882

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