HCID 178483294, compound → HCID 178483284, compound

HRID 231445Notes

Reaction equation

HRID 231445 reaction equation
[CH3:1][N:2]([CH2:6][CH2:7][C:8]1[CH:13]=[C:12]([N+:14]([O-])=O)[C:11]([F:17])=[CH:10][C:9]=1[Cl:18])[SH:3](=[O:5])=[O:4]>C(O)(=O)C.[Pt]=O>[CH3:1][N:2]([CH2:6][CH2:7][C:8]1[CH:13]=[C:12]([NH2:14])[C:11]([F:17])=[CH:10][C:9]=1[Cl:18])[SH:3](=[O:4])=[O:5]

Participants

4

Reactant 1

HCID 178483294HCID 178483294, compound

Product 1

HCID 178483284HCID 178483284, compoundYield 82.7%

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 176Acetic AcidSolvent

Procedure

By the method of Example 3, Step C, 1.0 g (0.0034 mole) of N-methyl-N-(2-chloro-4-fluoro-5-nitrobenzyl)methylsulfonamide was hydrogenated in the presence of 0.3 g of platinum oxide in 90 ml of glacial acetic acid, yielding 0.75 g of N-methyl-N-(2-chloro-4-fluoro-5aminobenzyl)methylsulfonamide as a yellow-tan solid, m.p. 108°-109° C. The nmr spectrum was consistent with the proposed structure.

Sources & evidence

ORD record
ord-7c44d8e7682e420a82db4aed7918251e
Source dataset
uspto-grants-1989_07
Patent number
US04846882

Reaction notes

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