Potassium Hydroxide → 1-Cyano-3-methylcyclohexane-1-carboxylic acid

HRID 231459Notes

Reaction equation

HRID 231459 reaction equation
[CH3:1][CH:2]1[CH2:7][CH2:6][CH2:5][C:4]([C:13]#[N:14])([C:8]([O:10]CC)=[O:9])[CH2:3]1.[OH-].[K+]>>[C:13]([C:4]1([C:8]([OH:10])=[O:9])[CH2:5][CH2:6][CH2:7][CH:2]([CH3:1])[CH2:3]1)#[N:14]

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 20032648Ethyl 3-methyl-1-cyanocyclohexanecarboxylate

Product 1

HCID 198007731-Cyano-3-methylcyclohexane-1-carboxylic acid

Procedure

This ester is hydrolyzed by heating with ethanolic potassium hydroxide solution. Neutralization, extraction with methyl tert.-butyl ether and distillative removal of the solvent gives 1-cyano-3-methylcyclohexanecarboxylic acid.

Workup

  1. extractionNeutralization, extraction
  2. customwith methyl tert.-butyl ether and distillative removal of the solvent

Sources & evidence

ORD record
ord-2cd216ae7bb34f7280dc83604263c364
Source dataset
uspto-grants-1989_07
Patent number
US04846998

Reaction notes

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