HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium diisopropylamide → 1-(1-Cyano-3-methylcyclohexyl)-2-(4'-pentylbiphenyl-4-yl)ethane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Reactant | 3-Methylcyclohexane-1-carbonitrile | HCID 19800740 | — |
| Reactant | 1-Bromo-2-(4'-pentylbiphenyl-4-yl)ethane | HCID 20032617 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(1-Cyano-3-methylcyclohexyl)-2-(4'-pentylbiphenyl-4-yl)ethane | HCID 20091511 | — |
Reaction Steps
A mixture of 3.1 g of 3-methylcyclohexanecarbonitrile and 30 ml of THF has added to it at -78° a solution of lithium diisopropylamide (prepared from 3.3 g of diisopropylamine, 30 ml of THF and 19 ml of 1.6-molar butyllithium solution in hexane) and then a solution of 9.7 g of 1-bromo-2-(4'-pentylbiphenyl-4-yl)ethane in 30 ml of THF. Working up as in Example 1 gives 1-(1-cyano-3-methylcyclohexyl)-2-(4'-pentylbiphenyl-4-yl)ethane, m.p. 73°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04846998 |
| Source dataset | uspto-grants-1989_07 |
| ORD ID | ord-d65c46e3ffae4b9098bf1cbf9c0f73cf |
| Source note | uspto-grants-1989_07 |