Methyl Isocyanate → HCID 20032937, compound

HRID 231475Notes

Reaction equation

HRID 231475 reaction equation
[CH3:1][CH:2]1[C:7]([C:8]2[CH:9]=[CH:10][C:11]([NH2:14])=[N:12][CH:13]=2)=[N:6][NH:5][C:4](=[O:15])[CH2:3]1.[CH3:16][N:17]=[C:18]=[O:19]>CS(C)=O>[CH3:1][CH:2]1[C:7]([C:8]2[CH:9]=[CH:10][C:11]([NH:14][C:18]([NH:17][CH3:16])=[O:19])=[N:12][CH:13]=2)=[N:6][NH:5][C:4](=[O:15])[CH2:3]1

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 20032965HCID 20032965, compound

Product 1

HCID 20032937HCID 20032937, compoundYield 48%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

A mixture of 0.4 g. (2 mmole) 4,5-dihydro-5-methyl-6-(2-amino-5-pyridyl)-3(2H)-pyridazinone, 10 ml. dimethyl sulphoxide and 0.24 ml. (4 mmole) methyl isocyanate was stirred for 16 hours at ambient temperature, evaporated in a vacuum and the residue triturated with water. There were obtained 0.25 g. of the title compound (48% of theory); m.p. 257°-259° C.

Workup

  1. additionA mixture of 0.4 g
  2. customevaporated in a vacuum
  3. customthe residue triturated with water
  4. customThere were obtained 0.25 g

Sources & evidence

ORD record
ord-52e86e344152434f8adec9ba422f24cd
Source dataset
uspto-grants-1989_07
Patent number
US04847251

Reaction notes

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