Benzene → Benzamide, N-(1,2,3,4-tetrahydro-2-methylisoquinolin-7-yl)-3,4,5-trimethoxy-

HRID 2314818Notes

Reaction equation

HRID 2314818 reaction equation
[C:38](=[O:39])([OH:40])[O-:41].[CH2:58]1[c:59]2[c:60]([cH:61][cH:62][cH:63][cH:64]2)[CH2:65][CH2:66][NH:67]1.[CH3:43][O:44][c:45]1[cH:46][c:47]([C:48](=[O:49])[Cl:50])[cH:51][c:52]([O:56][CH3:57])[c:53]1[O:54][CH3:55].[K+:42].[N+:24]([c:25]1[cH:26][c:27]2[c:28]([cH:29][cH:30][n+:31]([CH3:32])[cH:33]2)[cH:34][cH:35]1)([O-:36])=[O:37].[NH2:1][c:2]1[cH:3][cH:4][c:5]2[c:10]([cH:11]1)[CH2:9][N:8]([CH3:12])[CH2:7][CH2:6]2.[Na+:74].[Na+:75].[O-:76][C:77](=[O:78])[O-:79].[c:13]1([CH3:14])[cH:15][cH:16][c:17]([S:18]([O-:19])(=[O:20])=[O:21])[cH:22][cH:23]1.[cH:68]1[cH:69][cH:70][cH:71][cH:72][cH:73]1>>[NH:1]([c:2]1[cH:3][cH:4][c:5]2[c:10]([cH:11]1)[CH2:9][N:8]([CH3:12])[CH2:7][CH2:6]2)[C:48]([c:47]1[cH:46][c:45]([O:44][CH3:43])[c:53]([O:54][CH3:55])[c:52]([O:56][CH3:57])[cH:51]1)=[O:49]

Participants

11

Reactant 10

HCID 241BenzeneHCID 769Bicarbonate IonHCID 813Potassium CationHCID 923Sodium ion2×HCID 70461,2,3,4-TetrahydroisoquinolineHCID 19660Carbonate IonHCID 78282Benzoyl chloride, 3,4,5-trimethoxy-HCID 85570p-ToluenesulfonateHCID 129995062-Methyl-1,2,3,4-tetrahydroisoquinolin-7-amineHCID 21436757HCID 21436757, compound

Product 1

HCID 216591Benzamide, N-(1,2,3,4-tetrahydro-2-methylisoquinolin-7-yl)-3,4,5-trimethoxy-

Sources & evidence

ORD record
ord-83e932e98a0c44ecb1c64c0f3c8df44e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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