4-Aminophenol → HCID 20033021, compound

Participants

Reaction Steps

With cooling, 2.2 g of powdered potassium hydroxide are added to a solution of 2.1 g of 4-aminophenol in 50 ml of dimethylsulfoxide and the mixture is stirred for 1 hour to form a clear solution. To the batch are then added, in portions, 6 g of 2-methylsulfonyl-4-trifluoromethyl-5-phenylpyrimidine and the mixture is stirred for 4 hours at room temperature. The mixture is then poured into ice-water and extracted with ether. The washed and dried ethereal extracts yield a product of m.p. 123°-126° C., which is the title compound of formula ##STR21##

Provenance & Evidence