Ethanone, 1-(2,5-dichlorophenyl)- → 2',5'-Dichloro-3-dimethylaminoacrylophenone

Participants

Reaction Steps

A mixture of 31.0 g of 2',5'-dichloroacetophenone and 25 ml of N,N-dimethylformamide dimethyl acetal was heated on a steam bath for 6 hours, then evaporated to dryness in vacuo. The residue was slurried with hexane, filtered, and gave 35.3 g of 2',5'-dichloro-3-dimethylaminoacrylophenone as orange crystals, mp 83°-85° C.

Provenance & Evidence