反应详情

A mixture of 50.0 g of 3'-chloro-3-dimethylaminoacrylophenone, 25.0 g of 3-aminopyrazole-4-carbonitrile and 500 ml of glacial acetic acid was heated at reflux for 2 hours. The mixture went into solution upon heating and a precipitate formed after one hour of refluxing. The reaction mixture was filtered and the crystals collected were triturated with saturated aqueous sodium bicarbonate, filtered and washed with water and then dried to give 49.0 g of the product of the example as colorless crystals, mp 238°-240° C.

1. temperaturewas heated
2. temperatureat reflux for 2 hours
3. temperatureupon heating
4. customa precipitate formed after one hour
5. temperatureof refluxing
6. filtrationThe reaction mixture was filtered
7. customthe crystals collected
8. customwere triturated with saturated aqueous sodium bicarbonate
9. filtrationfiltered
10. washwashed with water
11. customdried