反应详情

A mixture of 6.0 g of 3-aminopyrazole-4-carbonitrile, 13.0 g of N-[3-[3-(dimethylamino)-1-oxo-2-propenyl]phenyl]acetamide and 100 ml of glacial acetic acid was heated at reflux for 4 hours. On standing at room temperature a precipitate formed. The precipitate was isolated, washed with hexane, then ether and dried. The solid was recrystallized from acetonitrile-N,N-dimethylformamide and gave the product of the example, mp 252°-254° C.

1. temperaturewas heated
2. temperatureat reflux for 4 hours
3. customOn standing at room temperature
4. customformed
5. customThe precipitate was isolated
6. washwashed with hexane
7. dry with materialether and dried
8. customThe solid was recrystallized from acetonitrile-N,N-dimethylformamide
9. customgave the product of the example, mp 252°-254° C.