P-Chloroacetophenone → 1-(4-Chlorophenyl)-3-(dimethylamino)but-2-en-1-one

Participants

Reaction Steps

A mixture of 25.0 g of 4-chloroacetophenone and 40 ml of N,N-dimethylacetamide dimethyl acetal was stirred and heated at reflux for 3 hours. The mixture was evaporated in vacuo to give a red solid. The solid was triturated with n-hexane and filtered. The solid was washed with n-hexane and dried to give 15.6 g of 1-(4-chlorophenyl)-3-(dimethylamino)-2-buten-1-one as red crystals, mp 103°-105° C.

Provenance & Evidence