反应详情

A mixture of 98.3 g of 2',5'-dichloro-3-dimethylaminoacrylophenone and 43.5 g of 3-aminopyrazole-4-carbonitrile in one liter of glacial acetic acid was heated at reflux for 63/4 hours. The reaction mixture was cooled and diluted with water to provide a precipitate which was collected, washed with water and dried in vacuo to give 107.6 g of 7-(2,5-dichlorophenyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile as pale yellow crystals, mp 202°-204° C.

1. temperaturewas heated
2. temperatureat reflux for 63/4 hours
3. temperatureThe reaction mixture was cooled
4. customto provide a precipitate which
5. customwas collected
6. washwashed with water
7. customdried in vacuo