HCID 4774693, compound → HCID 135671383, compound

Participants

Reaction Steps

To a stirred mixture of 46.8 g of 7-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile in 1.2 liters of glacial acetic acid under nitrogen and heated on a steam bath was added portionwise 30.0 g of sodium cyanoborohydride, heating and stirring was continued until all the solid was dissolved. The heat was removed and stirring was continued. A solid mass formed and was collected by filtration. The solid was washed with water, then with aqueous ammonia, followed by water again. The solid was dried in vacuo to give 29.1 g of the product of the example as a white solid, mp 208°-209° C.

Provenance & Evidence