Bacampicillin Hydrochloride → Bacampicillin

Participants

Reaction Steps

To a stirred suspension of dicyclohexylammonium 6β-bromopenicillanate (46.15 g, 100 mmol; as prepared in Example 3c, 1st crop) in water (800 ml) was added dropwise during 75 minutes a solution of bacampicillin hydrochloride (60.24 g, 120 mmol) in water (800 ml). After stirring for an additional 2 hours, the crystals were filtered off, washed with water (2×150 ml) followed by hexane (2×250 ml), and dried to yield 66.3 g (85.8%) of the desired compound.

Provenance & Evidence