Hydrochloric Acid → HCID 14281278, compound

Participants

Reaction Steps

A mixture of 4.0 g (15.6 mmol) of 8-(4-hydroxyphenylthio)-5,6,7,8-tetrahydroquinoline in 40 ml of acetic anhydride was heated under reflux for 2 hours. A reagent was then removed under reduced pressure and the residue was subjected to flash chromatography (Kieselgel 60; 5% ethyl acetate in dichloromethane). The thick yellow oil thus obtained was treated with ethereal hydrogen chloride to yield 3.4 g (49%) of 8-(4-acetoxyphenylthio)-5,6,7,8-tetrahydroquinoline hydrochloride.

Provenance & Evidence