反应详情

To a solution of 82.9 mg (0.3 mmole) 125 in a mixture of ethanol/ethylacetate 1:1 10% Pd/C (40 mg) was added. The flask was flushed 3 times with hydrogen and filled with hydrogen at 30 to 35 psi. The suspension was stirred vigorously at room temperature for 30 minutes. The catalyst was filtered off, the filtrate was evaporated in vacuo to dryness. The solid 126 was used for the next step without purification

1. additionwas added
2. customThe flask was flushed 3 times with hydrogen
3. additionfilled with hydrogen at 30 to 35 psi
4. filtrationThe catalyst was filtered off
5. customthe filtrate was evaporated in vacuo to dryness
6. customThe solid 126 was used for the next step without purification