4-(Trifluoromethyl)aniline → 1-Boc-4-(4-Trifluoromethyl-phenylamino)-piperidine

HRID 2315653Notes

Reaction equation

HRID 2315653 reaction equation
[F:15][C:16]([c:17]1[cH:18][cH:19][c:20]([NH2:21])[cH:22][cH:23]1)([F:24])[F:25].[F:26][C:27]([F:28])([F:29])[c:30]1[cH:31][c:32]([NH:33][CH:34]2[CH2:35][CH2:36][N:37]([C:38]([O:39][C:40]([CH3:41])([CH3:42])[CH3:43])=[O:44])[CH2:45][CH2:46]2)[cH:47][cH:48][cH:49]1.[O:1]=[C:2]1[CH2:3][CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1>>[CH:2]1([NH:21][c:20]2[cH:19][cH:18][c:17]([C:16]([F:15])([F:24])[F:25])[cH:23][cH:22]2)[CH2:3][CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1

Participants

4

Reactant 3

HCID 99644-(Trifluoromethyl)anilineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 37223301-Boc-4-(3-trifluoromethyl-phenylamino)-piperidine

Product 1

HCID 220291421-Boc-4-(4-Trifluoromethyl-phenylamino)-piperidine

Sources & evidence

ORD record
ord-0815281aa3304904a7119e0e30fc6f2b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

Loading…