Ethylamine → 1-(3-Methyl-butyl)-4-nitro-1H-pyrrole-2-carboxylic acid [2-(N,N'-diethylcarbamimidoyl)-ethyl]-amide

Participants

Reaction Steps

Compound 272 was synthesized from cyanoethylamide 242 as described above for compound 270 using ethylamine (3 ml). ES MS: 351.53. (M+H+). H1-NMR (DMSO-d6): 0.86-0.88 (d, 6H, CH3-isopentyl), 1.07-1.17 (t, 6H, CH3-ethyl), 1.42-1.60 (m, 3H, CH & CH2—CH), 2.67-2.72 (t, 2H, CH2 CH2-amidine), 3.12-3.21 (m, 2H, CH2-ethyl), 3.36-3.50 (m, 4H, CH2—NHCO and CH2-ethyl), 4.33-4.38 (t, 2H, CH3—N), 7.39 and 8.20 (d, 1H, pyrrole), 8.63-8.71 (NH-amidine), 9.30 (t, 1H, NHCO).

Provenance & Evidence