反应详情

Compound 274 was synthesized from cyanoethylamide 242 as described above for compound 270 using 1,3-propylamine (6 ml). ES MS: 364.37 (M+H+). H1-NMR (DMSO-d6): 0.85-0.87 (d, 6H, CH3), 1.42-1.61 (m, 3H, CH & CH2—CH of pyrrole), 1.79-1.84 (m, 2H, CH2CH2 CH2), 2.55-2.60 (t, 2H, CH2 CH2-amidine), 3.25 (m, 4H, CH2 CH2 CH2), 3.40-3.52 (m, 2H, CH2—NHCO), 4.33-4.38 (t, 2H, CH2-N), 7.48 and 8.18 (d, 1H, pyrrole), 8.15 and 9.78 (bs, 1H, NH-amidine), 8.89 (t, 1H, NHCO).