Ethanol → HCID 67946054, compound

Participants

Reaction Steps

A solution of 4.27 g (0.01 mol) of 6-(α-acetyl-N-methyl-3-nitrostyrenesulfonamido)caproic acid ethyl ester in 30 ml of ethanol is treated with 1.15 g (0.01 mol) of 3-aminocrotonic acid methyl ester and 1.16 g (0.005 mol) of DL-camphor-10-sulfonic acid analogously to Example 1. After chromatography on silica gel with methylene chloride/ethyl acetate (9:1) as the elution agent the crude product is recrystallized from methylene chloride/ether. There are obtained 3.4 g (65%) of 5-{[5-(ethoxycarbonyl)pentyl]methylsulfamoyl}-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)nicotinic acid methyl ester, m.p. 83°-86°, as a colorless crystalline powder.

Provenance & Evidence