反应详情

In a 1-liter flask fitted with a stirrer and reflux condenser, 61.8 grams of N-acetyl-4-n-dodecyl-2-nitroaniline (prepared in Example 2b), 320 ml of ethanol and 64 ml of 40% aqueous potassium hydroxide solution are heated for 1 hour under reflux. The reaction mixture is cooled and then poured into 1.5 liters of water. The crude product is isolated by filtration, washed repeatedly with cold water and recrystallized from methanol. The above-named product is isolated as a solid melting at 69°-71° C. in a yield of 45 grams.

1. customIn a 1-liter flask fitted with a stirrer
2. temperaturereflux condenser
3. temperatureunder reflux
4. temperatureThe reaction mixture is cooled
5. customThe crude product is isolated by filtration
6. washwashed repeatedly with cold water
7. customrecrystallized from methanol