Dichloromethane → 1-(benzo[d][1,3]dioxol-5-yl)-N-(2-tert-butyl-6-fluoro-1-((tetrahydro-2H-pyran-3-yl)methyl)indolin-5-yl)cyclopropanecarboxamide

HRID 2316484Notes

Reaction equation

HRID 2316484 reaction equation
[Cl:38][CH2:39][Cl:40].[O:1]1[CH2:2][O:3][c:4]2[c:5]1[cH:6][cH:7][c:8]([C:10]1([C:13](=[O:14])[NH:15][c:16]3[cH:17][c:18]4[c:22]([cH:23][c:24]3[F:25])[NH:21][CH:20]([C:26]([CH3:27])([CH3:28])[CH3:29])[CH2:19]4)[CH2:11][CH2:12]1)[cH:9]2.[O:30]1[CH2:31][CH:32]([CH:36]=[O:37])[CH2:33][CH2:34][CH2:35]1>>[O:1]1[CH2:2][O:3][c:4]2[c:5]1[cH:6][cH:7][c:8]([C:10]1([C:13](=[O:14])[NH:15][c:16]3[cH:17][c:18]4[c:22]([cH:23][c:24]3[F:25])[N:21]([CH2:36][CH:32]3[CH2:31][O:30][CH2:35][CH2:34][CH2:33]3)[CH:20]([C:26]([CH3:27])([CH3:28])[CH3:29])[CH2:19]4)[CH2:11][CH2:12]1)[cH:9]2

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 10129928Oxane-3-carbaldehydeHCID 59129318HCID 59129318, compound

Product 1

HCID 670439761-(benzo[d][1,3]dioxol-5-yl)-N-(2-tert-butyl-6-fluoro-1-((tetrahydro-2H-pyran-3-yl)methyl)indolin-5-yl)cyclopropanecarboxamide

Sources & evidence

ORD record
ord-8dca28f74aed4a2e8b27b3257ece508a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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