Bromide ion → tert-Butyl 4-hydroxy-4-(2-methylphenyl)piperidine-1-carboxylate

HRID 2316581Notes

Reaction equation

HRID 2316581 reaction equation
[Br-:15].[C:1](=[O:2])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])[N:8]1[CH2:9][CH2:10][C:11](=[O:14])[CH2:12][CH2:13]1.[CH2:24]([O:25][CH2:26][CH3:27])[CH3:28].[c:16]1([CH3:23])[c:17]([Mg+:22])[cH:18][cH:19][cH:20][cH:21]1>>[C:1](=[O:2])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])[N:8]1[CH2:9][CH2:10][C:11]([OH:14])([c:17]2[c:16]([CH3:23])[cH:21][cH:20][cH:19][cH:18]2)[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 259Bromide ionHCID 3283Diethyl EtherHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 178424302HCID 178424302, compound

Product 1

HCID 49760233tert-Butyl 4-hydroxy-4-(2-methylphenyl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-edfacfce4f11401c8226df57c3aea7ef
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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