関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 5-Bromo-2-thiophenesulfonamide | HCID 1241304 | — |
| 反応物 | 4-Mercaptophenylacetic acid | HCID 3390511 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 5-(4-Carboxymethylphenylthio)thiophene-2-sulfonamide | HCID 20033693 | — |
反応手順
4-Mercaptophenylacetic acid (2.3 g) was dissolved in dimethylformamide under a nitrogen atmosphere and 1.8 g of potassium hydroxide dissolved in a minimum amount of water was added. 5-bromothiophene-2-sulfonamide (3.3 g) dissolved in dimethylformamide was added and the mixture heated at 120° C. for 2 hours. After cooling to room temperature water was added to the reaction mixture, the pH was adjusted to 8.6 and the mixture was extracted with ethyl acetate. The aqueous phase was separated and acidified, causing a solid to precipitate. The solid was collected by filtration and dried under vacuum to a weight of 3.25 g.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04847289 |
|---|
| 出典データセット | uspto-grants-1989_07 |
|---|
| ORD ID | ord-e9ec0aeb8d5c4266906869950d3ea639 |
|---|
| 出典メモ | uspto-grants-1989_07 |
|---|
