Sulfuric Acid → HCID 20033698, compound

Participants

Reaction Steps

To a solution of sulfuric acid (76.7 ml) in water (76.7 ml), cooled to 0° C. was added a solution of compound from Step F (5.2 g, 11.5 mmol) in methanol (76.7 ml) and the reaction mixture was stirred at room temperature for 1 hour. Water was added, extracted with ethyl acetate and the organic layers were washed with saturated NaaHCO3 solution and brine. Drying and solvent evaporation gave an oil (4.4 g) and column chromatography (silica gel, 40% ethyl acetate-hexane) gave a solid product (2.3 g, 56%); m.p. 119°-121° C.

Provenance & Evidence