Dimethylamine → HCID 20033684, compound

Participants

Reaction Steps

To a solution of product from Step C, (1.2 g, 3.3 mmol) in ethanol (16.5 ml) was added formaldehyde (0.3 ml, 37% in water, 3.6 mmol) and dimethylamine (0.8 ml, 40% in water, 6.6 mmol). The reaction was refluxed for 3 hours and then stirred at room temperature overnight. The solution was concentrated, 3N HCl added and extracted with ethyl acetate. The aqueous phase was made basic with saturated bicarbonate solution and extracted with ethyl acetate. Drying and solvent evaporation gave and oil (1.1 g). Column chromatography (silica gel, 5% methanol-CHCl3) gave the title compound (0.8 g, 57%).

Provenance & Evidence