Lactic Acid → Hydroxyacetic acid--2-hydroxypropanoic acid (1/1)

Participants

Reaction Steps

To 160 g of 85% aqueous lactic acid solution and 38 g of glycolic acid was added 6.8 g of Dowex 50W and the mixture was heated in a nitrogen atmosphere under reduced pressure for 6 hours in a manner such that the inside temperature and pressure were initially 105° C. and 350 mmHg, respectively, and finally 150° C. and 30 mmHg, respectively, while removing the water distilled. Then, 6.8 g of Dowex 50W was added and the reaction was further carried out at 175° C. and 3-5 mmHg for 40 hours. While hot, the reaction mixture was filtered to thereby remove the Dowex 50W. The filtrate was cooled to give a lactic acid-glycolic acid copolymer.

Provenance & Evidence