HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloronicotinamide → 2-[4-(2,3-Dihydroxypropyl)piperazin-1-yl]nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloronicotinamide | HCID 82588 | — |
| Reactant | 3-(Piperazin-1-yl)propane-1,2-diol | HCID 111002 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-[4-(2,3-Dihydroxypropyl)piperazin-1-yl]nicotinamide | HCID 20032007 | 34.9% |
Reaction Steps
Operation was carried out in a manner similar to the one described in Example 2, using 1.6 g of 2-chloronicotinamide, 3.2 g of 1-(2,3-dihydroxypropyl)piperazine and 30 ml ethanol and refluxing overnight. Column purification of the residue gave 1 g of 2-[4-(2,3-dihydroxypropyl)piperazin-1-yl]nicotinamide, which, recrystallized from acetone, melted at 140°-142° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04849422 |
| Source dataset | uspto-grants-1989_07 |
| ORD ID | ord-0ef617aa10c541aea1bf538ef375577c |
| Source note | uspto-grants-1989_07 |