2-Chloropyridine → 3-[4-(Pyridin-2-yl) piperazin-1-yl]propane-1,2-diol dihydrochloride

Participants

Reaction Steps

Operation was carried out in a manner similar to the one previously described, using 2-chloropyridine and 1-(2,3-dihydroxypropyl) piperazine. The residue obtained after evaporation to dryness was dissolved in a small amount of concentrated hydrochloric acid and diluted with isopropanol. After resting, 3-[4-(pyridin-2-yl) piperazin-1-yl]propane-1,2-diol dihydrochloride melting at 238°-242° C., was obtained with the 53.6% yield.

Provenance & Evidence