HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloronicotinic acid → 2-[4-(2,3-Dihydroxypropyl)piperazin-1-yl]pyridine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloronicotinic acid | HCID 76258 | — |
| Reactant | 3-(Piperazin-1-yl)propane-1,2-diol | HCID 111002 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-[4-(2,3-Dihydroxypropyl)piperazin-1-yl]pyridine-3-carboxylic acid | HCID 20032010 | — |
Reaction Steps
Grams 32 of 1-(2,3-dihydroxypropyl)piperazine and 15.7 g of 2-chloronicotinic acid in 500 ml dioxane were refluxed for 8 hours. The reaction mixture was cooled, settled, the solvent separated and removed. The residue was triturated under heating with absolute ethanol and gave 16.2 g of 2-[4-(2,3-dihydroxypropyl)piperazin-1-yl]nicotinic acid melting at 210°-212° C. (with decomposition)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04849422 |
| Source dataset | uspto-grants-1989_07 |
| ORD ID | ord-2f0badfe41a146dc9ebfbc463ad6b4d4 |
| Source note | uspto-grants-1989_07 |