2-Chloronicotinic acid → HCID 20032011, compound

Participants

Reaction Steps

Grams 5 of 1-(2,3-dihydroxypropyl)homopiperazine and 2.25 g of 2-chloronicotinic acid in 50 ml dioxane were refluxed for 24 hours. The reaction mixture was evaporated to dryness and the residue was purified on column eluting with ethanol:ammonium hydroxyde (95:5). The fractions containing the product were dried and the residue, triturated with acetonitrile, gave 1.3 g of 2-[4-(2,3-dihydroxypropyl)homopiperazin-1-yl]nicotinic acid, melting at 70°-77° C. (with decomposition).

Provenance & Evidence