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2-Chloronicotinic acid → 2-[4-(3-Hydroxypropyl)piperazin-1-yl]nicotinic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chloronicotinic acid | HCID 76258 | — |
| 反応物 | Piperazin-1-ylpropanol | HCID 79207 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 2-[4-(3-Hydroxypropyl)piperazin-1-yl]nicotinic acid | HCID 20031998 | — |
反応手順
Grams 8.65 of 1-(3-hydroxypropyl)piperazine and 4.7 g of 2-chloronicotinic acid in 100 ml dioxane were refluxed for 6 hours. The reaction mixture was cooled and settled. The residual oil, crystallized from 95° ethanol, gave 2.3 g of 2-[4-(3-hydroxypropyl)piperazin-1-yl]nicotinic acid, melting at 222°-225° C. (with decomposition).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04849422 |
| 出典データセット | uspto-grants-1989_07 |
| ORD ID | ord-516657a43b184a9dbceb122c90d21b94 |
| 出典メモ | uspto-grants-1989_07 |