反应详情

Grams 3 of 1-(2-hydroxypropyl)piperazine and 1.6 g of 2-chloronicotinic acid in 50 ml dioxane were refluxed for 2 days. The react ion mixture was cooled, then allowed to rest for 2 days, the solvent was removed and the residue was crystallized from absolute ethanol to give 1.2 g of 2-[4-(2-hydroxypropyl)piperazin-1-yl]nicotinic acid, melting at 222°-223° C. (with decomposition).

1. temperatureThe react ion mixture was cooled
2. customthe solvent was removed
3. customthe residue was crystallized from absolute ethanol