反应详情

Grams 5.9 of 1-(2-hydroxyethoxyethyl)piperazine and 2.7 g of 2-chloronicotinic acid in 50 ml dioxane were refluxed for 3 days. The reaction mixture was then cooled and allowed to rest for 2 days, afterwards the solvent was removed and the residue crystallized from absolute ethanol, gave 1.1 g of 2-{4-[2-(2-hydroxy ethoxy)ethyl]piperazin-1-yl}nicotinic acid melting at 172°-174° C.

1. temperatureThe reaction mixture was then cooled
2. customafterwards the solvent was removed
3. customthe residue crystallized from absolute ethanol