HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-2-(methylthio)pyrimidine-5-carboxylic acid ethyl ester → HCID 54279591, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-2-(methylthio)pyrimidine-5-carboxylic acid ethyl ester | HCID 80008 | — |
| Reactant | 3-(Piperazin-1-yl)propane-1,2-diol | HCID 111002 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 54279591 | HCID 54279591 | — |
Reaction Steps
Grams 4.6 of 2-methylthio-4-chloropyrimidine-5-carboxylic acid ethyl ester and 6.4 g of 1-(2,3-dihydroxypropyl)piperazine in 50 ml dioxane were refluxed for 30 minutes. The mixture was cooled and settled, then the solvent was evaporated and the dried residue purified on column eluting with chloroform:methanol (9:1). Grams 4.8 of 2-methylthio-4-[4-(2,3-dihydroxypropyl)piperazin-1-yl]pyrimidine-5-carboxylic acid ethyl ester as an oil, were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04849422 |
| Source dataset | uspto-grants-1989_07 |
| ORD ID | ord-ec65ab8427454d47a1e4c69debec223c |
| Source note | uspto-grants-1989_07 |