Water → HCID 14578902, compound

Participants

Reaction Steps

To a mixture of 92 g of 4,4a,5,6-tetrahydro[1]benzothiepino[5,4-c]pyridazin-3(2H)-one in 920 ml of acetic acid is added 64 g of bromine dropwise at 50°-60° C., and the mixture is kept at the same temperature for an hour and poured into a large quantity of water. The precipitated crystals are collected by filtration, and washed with warm water and then with ethanol. The crystals are dried to give 85 g of 5,6-dihydro-[1]benzothiepino[5,4-c]pyridazin-3(2H)-one, melting at 311°-313° C. with decomposition.

Provenance & Evidence